Peripheral Artery Disease (PAD) is a common, progressive circulatory problem that affects more than 20 million people in the U.S. and over 202 million people globally1,2

PAD develops when arteries become clogged with plaque that limits blood flow to the leg. The blockage can cause poor circulation, pain while walking, and changes in skin color.

PAD often advances to critical limb ischemia (CLI), the most severe form of the disease. CLI symptoms significantly increase in severity: pain when resting, open sores, and/or life-threatening conditions such as infection and gangrene. Left untreated, 50% of patients with CLI will undergo an amputation or die within the first year.3

Figure 1

PAD is usually caused by atherosclerosis, a build-up of plaque in the arteries (Figure 1). Diabetes, smoking, high blood pressure, age, obesity and high cholesterol are all risk factors related to PAD. Genetic factors, family history, dietary factors and lack of exercise also increase the risk of PAD.

For informational purposes only. You should always consult with your doctor when seeking medical advice or considering treatment.

  1. Yost M, The Sage Group 2016. [Press Release]
  2. Fowkes GR, Rudan D, Rudan I, et al. Comparison of global estimates of prevalence and risk factors for peripheral artery disease in 2000 and 2010: a systematic review and analysis. Lancet. 2013;382(9901):1329-1340.
  3. Hirsch AT, Jaskal ZJ, Hertzer NR, et al. ACC/AHA 2005 guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic): executive summary a collaborative report from the American Association for Vascular Surgery/Society for Vascular Surgery, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, Society of Interventional Radiology, and the ACC/AHA Task Force on Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients With Peripheral Arterial Disease) endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation; National Heart, Lung, and Blood Institute; Society for Vascular Nursing; TransAtlantic Inter-Society Consensus; and Vascular Disease Foundation. J Am Coll Cardiol. 2006;47(6):1239-312.
  4. Yost M, The Sage Group 2017. [Press Release]
  5. Yost M, The Sage Group; NCVH 2016.


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